In a small initial test in people, researchers have shown that a single infusion of a novel gene-editing treatment can reduce cholesterol, the fatty substance that clogs and hardens arteries over time. The experiment was carried out in 10 participants with an inherited condition that causes extremely high LDL, or …

More than half the world’s population is expected to be overweight or obese by 2035. Excess weight is often linked with cardiovascular disease: It can lead to higher blood pressure or cholesterol, which increases the risk of heart attack and stroke. Now, the makers of the popular weight-loss drug Wegovy …

When Hannah Lovaglio’s children were born, she didn’t think twice about the newborn health screening they received in the hospital. The routine test uses a few drops of blood from a heel prick to test for dozens of potentially fatal or disabling genetic diseases. “I assumed that this was for …

The blockbuster weight loss drug Wegovy has a new rival. Today, the US Food and Drug Administration approved a new drug for weight management called Zepbound, made by American pharmaceutical company Eli Lilly. The weekly injectable drug is meant for adults who are overweight or obese and have at least …

Lawrence Faucette, the 58-year-old patient with terminal heart disease who was the second person to receive a genetically engineered pig heart, died on October 30, according to a statement from the University of Maryland Medical Center in Baltimore, where the transplant was performed. Faucette received the transplant on September 20 …

In 2010, a 19-year-old migrant farmworker from Mexico arrived at a sugarcane plantation in Louisiana unknowingly carrying a deadly virus. His symptoms were mild at first: fatigue, shoulder pain, and numbness in one of his hands. As his condition worsened, he was admitted to a hospital in New Orleans. There, …

Amber Pearson has had a severe form of obsessive compulsive disorder since she was in high school. She would wash her hands so much they became raw and bled. Her bedtime routine easily took 45 minutes because it involved checking that all the doors and windows were closed and the …

Two companies have launched clinical trials to see if they can restore hearing to children with a rare type of genetic deafness. Akouos and Decibel Therapeutics, both based in Boston, are testing experimental therapies in children with severe hearing loss due to variations in a gene called OTOF. A third …

This month, the Cambodian government reported that two people there died of highly pathogenic avian influenza, or H5N1 bird flu, after being exposed to infected poultry. For people, the risk of getting infected is low, but outbreaks in animals have been rising worldwide, wiping out chicken flocks and wild bird …

Around the world, there aren’t enough donor kidneys available for everyone who needs one. Scientists are hoping pig kidneys could help ease the shortage, but first they must make sure the organs can keep working after transplant. In a step toward that goal, Massachusetts-based biotech company eGenesis reports today that …